Àá½Ã¸¸ ±â´Ù·Á ÁÖ¼¼¿ä. ·ÎµùÁßÀÔ´Ï´Ù.
KMID : 0043320200430080773
Archives of Pharmacal Research
2020 Volume.43 No. 8 p.773 ~ p.787
Therapeutic effects of ginsenosides on breast cancer growth and metastasis
Jin Yu-Jin

Huynh Diem Thi Ngoc
Nguyen Thuy Le Lam
Jeon Hye-Su
Heo Kyung-Sun
Abstract
Breast cancer is the most common cause of cancer-related deaths among women worldwide. Thus, the development of new and effective low-toxicity drugs is vital. The specific characteristics of breast cancer have allowed for the development of targeted therapy towards each breast cancer subtype. Nevertheless, increasing drug resistance is displayed by the changing phenotype and microenvironments of the tumor through mutation or dysregulation of various mechanisms. Recently, emerging data on the therapeutic potential of biocompounds isolated from ginseng have been reported. Therefore, in this review, various roles of ginsenosides in the treatment of breast cancer, including apoptosis, autophagy, metastasis, epithelial-mesenchymal transition, epigenetic changes, combination therapy, and drug delivery system, have been discussed.
KEYWORD
Breast cancer, Cell growth, Ginsenoside, Metastasis, Epithelial-mesenchymal transition, Cancer resistance
FullTexts / Linksout information
Listed journal information
SCI(E) MEDLINE ÇмúÁøÈïÀç´Ü(KCI)